Publikationen
Grossmann K, Risch M, Markovic A, Aeschbacher S, Weideli OC, Velez L, Kovac M, Pereira F, Wohlwend N, Risch C, Hillmann D, Lung T, Renz H, Twerenbold R, Rothenbühler M, Leibovitz D, Kovacevic V, Klaver P, Brakenhoff TB, Franks B, Mitratza M, Downward GS, Dowling A, Montes S, Veen D, Grobbee DE, Cronin M, Conen D, Goodale BM, Risch L; COVID-19 remote early detection (COVID-RED) consortium. Sex-specific differences in physiological parameters related to SARS-CoV-2 infections among a national cohort (COVI-GAPP study). PLoS One. 2024 Mar 6;19(3):e0292203. doi: 10.1371/journal.pone.0292203. PMID: 38446766; PMCID: PMC10917257
Keaton JM, Kamali Z, Xie T, Vaez A, Williams A, Goleva SB, ..., Warren HR. Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits. Nat Genet. 2024 Apr 30. doi: 10.1038/s41588-024-01714-w.
Mahboube Ganji-Arjenaki, Zoha Kamali, Evangelos Evangelou, Helen R. Warren, He Gao, Georgios Ntritsos, ...Ahmad Vaez. Prioritization of Kidney Cell Types Highlights Myofibroblast Cells in Regulating Human Blood Pressure. Kidney International Reports 2024; https://doi.org/10.1016/j.ekir.2024.03.001.
Nagarajan P, Winkler TW, Bentley AR, Miller CL, Kraja AT, Schwander K, ..., Wang H. A Large-Scale Genome-Wide Study of Gene-Sleep Duration Interactions for Blood Pressure in 811,405 Individuals from Diverse Populations. medRxiv [Preprint]. 2024 Mar 8:2024.03.07.24303870. doi: 10.1101/2024.03.07.24303870. PMID: 38496537; PMCID: PMC10942520.
Bakker MK, Kanning JP, Abraham G, Martinsen AE, Winsvold BS, Zwart JA, Bourcier R, Sawada T, Koido M, Kamatani Y, Morel S, Amouyel P, Debette S, Bijlenga P, Berrandou T, Ganesh SK, Bouatia-Naji N, Jones G, Bown M, Rinkel GJE, Veldink JH, Ruigrok YM; HUNT All-In Stroke, CADISP group, International Consortium for Blood Pressure, International Headache Genetics Consortium, International Stroke Genetics Consortium (ISGC) Intracranial Aneurysm Working Group. Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity. Stroke. 2023 Mar;54(3):810-818.
Telser J, Grossmann K, Weideli OC, Hillmann D, Aeschbacher S, Wohlwend N, Velez L, Kuhle J, Aleksandra M, Benkert P, Risch C, Conen D, Risch M, Risch L (2023) Concentrations of Serum Brain Injury Biomarkers Following SARS-CoV-2 Infection in Individuals with and without Long-COVID-Results from the Prospective Population-Based COVI-GAPP Study. Diagnostics 2023, 13, 2167. Zur Publikation
Wohlwend NF, Grossmann K, Aeschbacher S, Weideli OC, Telser J, Risch M, Conen D, Risch L (2023) The association of suPAR with cardiovascular risk factors in young and healthy adults. Diagnostics. 13, no. 18: 2938. https://doi.org/10.3390/diagnostics13182938
Young WJ, Haessler J, Benjamins J-W, Repetto L, Yao J, Isaacs A et al. Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease. Nat Commun 2023; 14(1):1411. doi: 10.1038/s41467-023-36997-w.
Benkert P, Meier S, Schaedelin S, Manouchehrinia A, Yaldizli Ö, Maceski A, ... & Zecca, C. (2022) Serum neurofilament light chain for individual prognostication of disease activity in people with multiple sclerosis: a retrospective modelling and validation study. The Lancet Neurology, 21(3), 246 - 257. Zur Publikation
Grossmann K, Aeschbacher S, Wohlwend N, Blum S, Weideli OC, Telser J, Risch M, Risch L, Conen D. (2022) Smoking and high-sensitivity troponin I levels in young and healthy adults from the general population. MDPI Applied Sciences. https://doi.org/10.3390/app12199777
Joseph, Christina B.; Mariniello, Marta; Yoshifuji, Ayumi et al. Meta-GWAS Reveals Novel Genetic Variants Associated with Urinary Excretion of Uromodulin. JASN 33(3):p 511-529, March 2022. | DOI: 10.1681/ASN.2021040491
Narula S, Mohammadi-Shemirani P, Aeschbacher S, Chong MR, Le A, Thériault S, Grossman K, Paré G, Risch L, Risch M, Conen D. Genetic Predisposition to High Blood Pressure and Out-of-Office Hypertension: Insights from a Population Sample in Liechtenstein. medRxiv 2022.12.21.22282423; doi: https://doi.org/10.1101/2022.12.21.22282423
Risch M, Grossmann K, Aeschbacher S, Weideli OC, Kovac M, Pereira F, ... & Risch L (2022) Investigation of the use of a sensor bracelet for the pre-symptomatic detection of changes in physiological parameters related to COVID-19: an interim analysis of a prospective cohort study (COVI-GAPP). BMJ Open, 12(6), e058274. Zur Publikation
Taylor-Bateman V, Gill D, Georgakis MK, Malik R, Munroe P, Traylor M; International Consortium of Blood Pressure (ICBP). Cardiovascular Risk Factors and MRI Markers of Cerebral Small Vessel Disease: A Mendelian Randomization Study. Neurology. 2022 Jan 24;98(4):e343-e351. doi: 10.1212/WNL.0000000000013120. PMID: 34845052.
Thériault S, Imboden M, Biggs ML, Austin TR, Aeschbacher S, Schaffner E, Brody JA, Bartz TM, Risch M, Grossmann K, Lin HJ, Soliman EZ, Post WS, Risch L, Krieger JE, Pereira AC, Heckbert SR, Sotoodehnia N, Probst-Hensch NM and Conen D. Genome-wide analyses identify SCN5A as a susceptibility locus for premature atrial contraction frequency. iScience. 2022;25:105210.
Warren H, Edwards T, Ahmad Vaez et al. Genome-wide analysis in over 1 million individuals reveals over 2,000 independent genetic signals for blood pressure, 10 March 2022, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-1409164/v1]
Young WJ, Lahrouchi N, Isaacs A, Duong T, Foco L, Ahmed F, Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways. Nat Commun. 2022;13:5144
Brakenhoff TB, Franks B, Goodale BM, van de Wijgert J, Montes S, Veen D, Fredslund EK, Rispens T, Risch L, Dowling AV, Folarin AA, Bruijning P, Dobson R, Heikamp T, Klaver P, Cronin M and Grobbee DE. A prospective, randomized, single-blinded, crossover trial to investigate the effect of a wearable device in addition to a daily symptom diary for the Remote Early Detection of SARS-CoV-2 infections (COVID-RED): a structured summary of a study protocol for a randomized controlled trial. Trials. 2021;22:694.
Filipovic, M., Reiner, M. F., Rittirsch, S., Irincheeva, I., Aeschbacher, S., Grossmann, K., ..., Risch, L., ... & Beer, J. H. (2021). Blood omega-3 fatty acids are inversely associated with albumin-creatinine ratio in young and healthy adults. Frontiers in cardiovascular medicine, 8, 398. Zur Publikation
Oechtering J, Schaedelin S, Benkert P, Müller S, Achtnichts L, Vehoff J, ... Kuhle J. Intrathecal Immunoglobulin M Synthesis is an Independent Biomarker for Higher Disease Activity and Severity in Multiple Sclerosis. Ann Neurol. 2021;90:477-489.
Aeschbacher, S., Mongiat, M., Bernasconi, R., Blum, S., Meyre, P., Krisai, P., ..., Risch, L., ... & Conen, D. (2020). Aldosterone-to-renin ratio and blood pressure in young adults from the general population. American Heart Journal, 222, 199-207. Zur Publikation
Ntalla, I., Weng, L. C., Cartwright, J. H., Hall, A. W., Sveinbjornsson, G., Tucker, N. R., ..., Risch, L., ... & Haessler, J. (2020). Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction. Nature communications, 11(1), 1-12. Zur Publikation
Schaffner A, Risch L, Aeschbacher S, Risch C, Weber MC, Thiel SL, Jüngert K, Pichler M, Grossmann K, Wohlwend N, Lung T, Hillmann D, Bigler S, Bodmer T, Imperiali M, Renz H, Kohler P, Vernazza P, Kahlert CR, Twerenbold R, Paprotny M, Conen D and Risch M. Characterization of a Pan-Immunoglobulin Assay Quantifying Antibodies Directed against the Receptor Binding Domain of the SARS-CoV-2 S1-Subunit of the Spike Protein: A Population-Based Study. J Clin Med. 2020;9.
Schaffner A, Risch L, Weber M, Thiel S, Jüngert K, Pichler M, Wohlwend N, Lung T, Ritzler M, Hillmann D, Copeland S, Renz H, Paprotny M, Risch M. Sustained SARS-CoV-2 nucleocapsid antibody levels in nonsevere COVID-19: a population-based study. Clin Chem Lab Med. 2020 Nov 19;59(2):e49-e51.
Surendran, P., Feofanova, E.V., Lahrouchi, N. et al. Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals. Nat Genet 52, 1314–1332 (2020). https://doi.org/10.1038/s41588-020-00713-x
Evangelou, E., Gao, H., Chu, C., Ntritsos, G., Blakeley, P., Butts, A. R., ... Risch, L., ... & Elliott, P. (2019). New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders. Nature human behaviour, 3(9), 950-961.
Giri, A., Hellwege, J.N., Keaton, J.M. et al. Trans-ethnic association study of blood pressure determinants in over 750,000 individuals. Nat Genet 51, 51–62 (2019). https://doi.org/10.1038/s41588-018-0303-9
Bernasconi, R., Aeschbacher, S., Blum, S., Mongiat, M., Girod, M., Todd, J., ... Risch, L., ... & Risch, M. (2018). Fibroblast growth factor 23 and renal function among young and healthy individuals. Clinical Chemistry and Laboratory Medicine (CCLM), 56(9), 1483-1489.
Egli, P., Aeschbacher, S., Bossard, M., Eggimann, L., Blum, S., Meyre, P., ... Risch, L., ... & Conen, D. (2018). Relationships of kidney injury molecule-1 with renal function and cardiovascular risk factors in the general population. Clinica chimica acta, 478, 13-17.
Evangelou E, Warren HR, Mosen-Ansorena D, Mifsud B, Pazoki R, Gao H, ... Risch L., ... & Caulfield MJ. (2018). Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nat Genet, 50(10):1412-1425.
Filipovic, M. G., Aeschbacher, S., Reiner, M. F., Stivala, S., Gobbato, S., Bonetti, N., ..., Risch, L., ... & Beer, J. H. (2018). Whole blood omega-3 fatty acid concentrations are inversely associated with blood pressure in young, healthy adults. Journal of hypertension, 36(7), 1548.
Roselli C, Chaffin MD, Weng LC, Aeschbacher S, Ahlberg G, Albert CM, ..., Risch L, ... & Ellinor PT (2018). Multi-ethnic genome-wide association study for atrial fibrillation. Nat Genet. 50(9):1225-1233.
Van Der Stouwe, J. G., Carmeli, C., Aeschbacher, S., Schoen, T., Krisai, P., Wenger, G., ... Risch, L., & Conen, D. (2018). Association of 24-hour blood pressure with urinary sodium excretion in healthy dults. American journal of hypertension, 31(7), 784-791.
Aeschbacher, S., Schoen, T., Dörig, L., Kreuzmann, R., Neuhauser, C., Schmidt-Trucksäss, A., ... Risch, L. & Conen, D. (2017). Heart rate, heart rate variability and inflammatory biomarkers among young and healthy adults. Annals of medicine, 49(1), 32-41.
Bossard, M., Thériault, S., Aeschbacher, S., Schoen, T., Kunz, S., von Rotz, M., ..., Risch, L., ... & Conen, D. (2017). Factors independently associated with cardiac troponin I levels in young and healthy adults from the general population. Clinical Research in Cardiology, 106(2), 96-104.
Christophersen IE, Rienstra M, Roselli C, Yin X, Geelhoed B, Barnard J, ... Risch L, ..., & Ellinor PT; AFGen Consortium (2017). Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation. Nat Genet. 49(6):946-952.
Fischer, A., Bossard, M., Aeschbacher, S., Egli, P., Cordewener, C., Estis, J., ..., Risch, L. & Conen, D. (2017). Plasma levels of endothelin-1 and renal function among young and healthy adults. Clinical Chemistry and Laboratory Medicine (CCLM), 55(8), 1202-1208.
Krisai, P., Aeschbacher, S., Repilado, F. J. R., Schoen, T., Reusser, A., Meier, M., ..., Risch, L. & Conen, D. (2017). Healthy lifestyle and glucagon-like peptide-1 in young and healthy adults: A population-based study. Preventive medicine, 101, 72-76.
Kofler, T., Bossard, M., Aeschbacher, S., Tabord, A., Ruperti Repilado, F. J., van der Lely, S., ..., Risch, L. & Conen, D. (2017). The interrelationships of birthweight, inflammation and body composition in healthy adults. European journal of clinical investigation, 46(4), 342-348.
Kofler, T., Thériault, S., Bossard, M., Aeschbacher, S., Bernet, S., Krisai, P., ..., Risch, L., ... & Conen, D. (2017). Relationships of measured and genetically determined height with the cardiac conduction system in healthy adults. Circulation: Arrhythmia and Electrophysiology, 10(1), e004735.
Maseli, A., Aeschbacher, S., Schoen, T., Fischer, A., Jung, M., Risch, M., Risch, L. & Conen, D. (2017). Healthy lifestyle and blood pressure variability in young adults. American journal of hypertension, 30(7), 690-699.
Schoen, T., Aeschbacher, S., Leuppi, J. D., Miedinger, D., Werthmüller, U., Estis, J., ..., Risch, L. & Conen, D. (2017). Subclinical sleep apnoea and plasma levels of endothelin-1 among young and healthy adults. Open Heart, 4(1), e000523
Von Rotz, M., Aeschbacher, S., Bossard, M., Schoen, T., Blum, S., Schneider, S., ..., Risch, L. & Conen, D. (2017). Risk factors for premature ventricular contractions in young and healthy adults. Heart, 103(9), 702-707.
Wain, L. V., Vaez, A., Jansen, R., Joehanes, R., Van Der Most, P. J., Erzurumluoglu, A. M., O’Reilly, PF, ... & Ehret GB. (2017) Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney. Hypertension 70 (3), e4-e19.
Warren, H. R., Evangelou, E., Cabrera, C. P., Gao, H., Ren, M., Mifsud, B., et al. (2017). Genome‑wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. Nature Genetics, 49(3), 403‑415.
Weng, LC., Lunetta, K.L., Müller-Nurasyid, M. et al. Genetic Interactions with Age, Sex, Body Mass Index, and Hypertension in Relation to Atrial Fibrillation: The AFGen Consortium. Sci Rep 7, 11303 (2017). https://doi.org/10.1038/s41598-017-09396-7
Aeschbacher, S., Metin, F., Bossard, M., Schoen, T., von Rotz, M., Mettler, H., ..., Risch, L. & Conen, D. (2016). Relationships of electrocardiographic parameters with ambulatory hypertension in young and healthy adults. International Journal of Cardiology, 202, 300-304.
Aeschbacher, S., Bossard, M., Ruperti Repilado, F. J., Good, N., Schoen, T., Zimny, M., ..., Risch, L. & Conen, D. (2016). Healthy lifestyle and heart rate variability in young adults. European journal of preventive cardiology, 23(10), 1037-1044.
Aeschbacher, S., Bossard, M., Schoen, T., Schmidlin, D., Muff, C., Maseli, A., ..., Risch, L. & Conen, D. (2016). Heart rate variability and sleep-related breathing disorders in the general population. The American Journal of Cardiology, 118(6), 912-917.
Aeschbacher, S., Schoen, T., Dörig, L., Kreuzmann, R., Neuhauser, C., Schmidt-Trucksäss, A., ... Risch, L. & Conen, D. (2016). Heart rate, heart rate variability and inflammatory biomarkers among young and healthy adults. Annals of medicine, 49(1), 32-41.
Bossard, M., Thériault, S., Aeschbacher, S., Schoen, T., Kunz, S., von Rotz, M., ..., Risch, L., … & Conen, D. (2016). Factors independently associated with cardiac troponin I levels in young and healthy adults from the general population. Clinical Research in Cardiology, 106(2), 96-104.
Kofler, T., Bossard, M., Aeschbacher, S., Tabord, A., Ruperti Repilado, F. J., van der Lely, S., ..., Risch, L. & Conen, D. (2016). The interrelationships of birthweight, inflammation and body composition in healthy adults. European journal of clinical investigation, 46(4), 342-348.
Krisai, P., Leib, S., Aeschbacher, S., Kofler, T., Assadian, M., Maseli, A., ..., Risch, L. & Conen, D. (2016). Relationships of iron metabolism with insulin resistance and glucose levels in young and healthy adults. European Journal of Internal Medicine, 32, 31-37.
Ruperti Repilado, F. J. R., Aeschbacher, S., Bossard, M., Schoen, T., Gugganig, R., van der Stouwe, J. G., ..., Risch, L., ... & Conen, D. (2016). Relationship of N-terminal fragment of pro-B-type natriuretic peptide and copeptin with erythrocytes-related parameters: A population-based study. Clinical Biochemistry, 49(9), 651-656.
Aeschbacher, S., Schoen, T., Bossard, M., van der Lely, S., Glättli, K., Todd, J., ..., Risch, L. & Conen, D. (2015). Relationship between high-sensitivity cardiac troponin I and blood pressure among young and healthy adults. American Journal of Hypertension, 28(6), 789-796.
Bossard, M., Pumpol, K., van der Lely, S., Aeschbacher, S., Schoen, T., Krisai, P., ..., Risch, L. & Conen, D. (2015). Plasma endothelin-1 and cardiovascular risk among young and healthy adults. Atherosclerosis, 239(1), 186-191.
Blum, J., Aeschbacher, S., Schoen, T., Bossard, M., Pumpol, K., Brasier, N., ..., Risch, L. & Conen, D. (2015). Prevalence of prediabetes according to hemoglobin A1c versus fasting plasma glucose criteria in healthy adults. Acta Diabetologica, 52(3), 631-632.
Krisai P, Aeschbacher S, Schoen T, Bossard M, van der Stouwe JG, Dörig L, ..., Risch L, Conen D (2015) Glucagon-like peptide-1 and blood pressure in young and healthy adults from the general population. Hypertension; 65:306-12.
Schoen, T., Hohmann, E. M., Van Der Lely, S., Aeschbacher, S., Reusser, A., Risch, M., Risch, L. & Conen, D. (2015). Plasma copeptin levels and ambulatory blood pressure characteristics in healthy adults. Journal of hypertension, 33(8), 1571-1579.
van der Stouwe, J. G., Aeschbacher, S., Krisai, P., Schoen, T., Meyre, P., Todd, J., ..., Risch, L. & Conen, D. (2015). Plasma levels of glucagon‐like peptide 1 and markers of obesity among young and healthy adults. Clinical Endocrinology, 83(5), 636-642.
Bossard, M., Aeschbacher, S., Schoen, T., Hochgruber, T., von Rotz, M., Blum, J., ..., Risch, L., Conen, D. (2014). Serum bilirubin levels and risk of prediabetes in young and healthy adults. International Journal of Cardiology, 171(2), e24-e25.
Aeschbacher, S., Schoen, T., Clair, C., Schillinger, P., Schönenberger, S., Risch, M., Risch, L. & Conen, D. (2014). Association of smoking and nicotine dependence with pre-diabetes in young and healthy adults. Swiss Medical Weekly, 144.
Conen, D., Aeschbacher, S., Thijs, L., Li, Y., Boggia, J., Asayama, K., ..., Risch, L. & Staessen, J. A. (2014). Age-specific differences between conventional and ambulatory daytime blood pressure values. Hypertension, 64(5), 1073-1079.
Marti-Soler H, Gubelmann C, Aeschbacher S, et al Seasonality of cardiovascular risk factors: an analysis including over 230 000 participants in 15 countries Heart 2014;100:1517-1523.
Conen, D., Schön, T., Aeschbacher, S., Paré, G., Frehner, W., Risch, M., Risch, L. (2013). Genetic and phenotypic Determinants of blood pressure and other cardiovascular risk factors (GAPP). Swiss Medical Weekly, 143:w13728.
J. Blum, S. Aeschbacher, T. Schoen, K. Pumpol, M. Risch, L. Risch, D. Conen, Prevalence of prediabetes in healthy adults using hemoglobin A1c versus fasting plasma glucose - The GAPP study, European Heart Journal, Volume 34, Issue suppl_1, 1 August 2013, P4290, https://doi.org/10.1093/eurheartj/eht309.P4290
Consortia overview:
- AFGen Consortia (www.afgen.org)
- CHARGE (www.chargeconsortium.com)
- COVID-RED (www.covid-red.eu/en)
- International Consortium for Blood Pressure (International Consortium for Blood Pressure (ICBP) - EGA European Genome-Phenome Archive (ega-archive.org)